Thrash It Out Online

Eye Floaters And Flashes

Menu
  • Curation Policy
Menu
Behcet disease – causes, symptoms, diagnosis, treatment, pathology

Behcet disease – causes, symptoms, diagnosis, treatment, pathology

Posted on August 10, 2019 by Jason Robles


Behcet disease, is a rare disorder and most
of the symptoms are thought to be a result of an autoimmune process involving the blood
vessels – it’s a type of vasculitis. Among the family of disorders that cause vasculitis,
Behcet’s is fairly unique because it causes inflammation in blood vessels of all sizes
– small, medium, and larges ones – on both the arterial and venous side of the circulation. The underlying cause of Behcet’s is unknown,
but there are a number of clues. The biggest clue is that the human leukocyte
antigen, or HLA, genes seem to play a role, and this is based on the fact that having
a specific type–the HLA-B51 type–predisposes individuals to having Behcet disease. HLA genes encode proteins found on the surface
of immune cells, and play a key role in regulation of those cells, and since the disease is a
result of an autoimmune process, it makes sense that the HLA-B51 proteins could be involved. Another, clue is that an individual’s response
to viral and bacterial infections may be involved. For example, some individuals with Behcet’s
generate relatively high levels of antibodies to Helicobacter pylori which may go on to
damage blood vessel walls. This is an example of molecular mimicry where
an antibody to a foreign pathogen starts to cross-react and damage the person’s own
tissue. Individuals with Behcet’s also seem to have
a weakened innate immune system, a higher proportion of autoreactive T cells and activated
neutrophils which destroy healthy tissue, and altered levels of T helper cells and cytokines. In sum, the clues span genetic and environmental
factors and both the innate and adaptive immune system. When looking at the blood vessels in particular
– the classic finding is seeing lymphocytes in the walls of capillaries, veins, and arteries
of all sizes making them inflamed and boggy; sometimes the inflammation can get so severe
that the tissue around the vessel begins to die off completely. These changes make the endothelial lining
more likely to develop blood clots or aneurysms. Since the inflammation is happening in blood
vessels of all sizes throughout the body, individuals with Behcet’s can develop a
wide-range of symptoms. Having said that, most individuals initially
present with recurrent oral ulcers. Relative to aphthous ulcers, the oral ulcers
of Behcet disease can be larger, more painful, and take a few weeks to heal – sometimes recurring
before a previous round of ulcers has resolved, which means that they can be almost continuously
present. The genital ulcers that develop are similarly
painful and can develop around the anus, vulva, or scrotum. Eye inflammation can also develop, and can
present a number of different ways. One is anterior uveitis which causes a painful
decrease in vision, redness of the conjunctiva, and hypopyon which is also known as sterile
pus because inflammatory cells enter the anterior chamber of the eye even though there is no
infection present. Another is posterior uveitis which causes
a painless decrease in vision and visual field floaters. On rare occasions, there can also be other
types of eye inflammation including involvement of the optic nerve itself. Not surprising – any sort of eye inflammation
can potentially lead to vision loss and is therefore one of the most serious aspects
of the Behcet’s. Some individuals can also develop skin conditions
like folliculitis or erythema nodosum – an inflammation of the fat cells underneath the
skin. As Behcet disease develops, it can vary quite
a lot between individuals since it can affect every organ system. Some individuals may have joint stiffness
and abdominal pain while others develop meningitis and kidney disease The clinical diagnosis is often made based
on an individual having a pattern of symptoms consistent with the disease, in particular
recurrent oral and genital ulcers, as well as eye and skin lesions. There is no specific blood work that’s typically
done, but one interesting and unique test that can be used is the pathergy test. In a pathergy test, an individual is pricked
on the skin and then reassessed 1-2 days later. Normally, a small pin prick would heal, but
many patients with Behcet disease don’t heal normally, and instead develop a skin
lesion or ulcer at that spot. Treatment for Behcet disease is typically
geared at suppressing the immune system to help alleviate the symptoms. That includes the use of medications like
corticosteroids, biologic agents that block the effect of tumor necrosis factor, and even
intravenous immunoglobulin which can alter the immune system’s activity. Okay – let’s recap, Behcet’s is a rare
autoimmune disease that affects small, medium, and large arteries and veins, as well as capillaries. The underlying mechanism is unclear, but blood
vessels show a pattern of lymphocyte infiltration and surrounding tissue necrosis. Classical features include recurrent oral
and genital ulcers, uveitis, and skin lesions, but the disease can affect nearly every organ
system. Thanks for watching, you can help support
us by donating on patreon, or subscribing to our channel, or telling your friends about
us on social media.

51 thoughts on “Behcet disease – causes, symptoms, diagnosis, treatment, pathology”

  1. truth in pack says:
    December 19, 2016 at 7:46 pm

    thank you.

    Reply
  2. andrej maric says:
    December 19, 2016 at 8:21 pm

    I love you

    Reply
  3. yvetvasan says:
    December 19, 2016 at 8:56 pm

    I was just asked today if I have ancestry from Turkey…is that also a similar factor to those diagnosed with Behcet's disease?
    Thank you.

    Reply
  4. simonsher says:
    December 20, 2016 at 2:00 am

    รญ dont know Who you are….. but whoever you are god bless you, keep it up. thanks

    Reply
  5. Liam Gutierrez says:
    December 20, 2016 at 3:29 am

    Please make also a video about DVT/VTE.

    Reply
  6. Jethu Reddy says:
    December 20, 2016 at 6:06 am

    God bless you

    Reply
  7. Asan Najat says:
    December 20, 2016 at 7:23 am

    ๐Ÿ‘๐Ÿ‘๐Ÿ‘๐Ÿ‘๐Ÿ‘๐Ÿ‘๐Ÿ‘

    Reply
  8. Suzan Eltahir says:
    December 20, 2016 at 10:54 am

    thank you. ..keep it up ๐Ÿ–’

    Reply
  9. ็œŸ่ฏš็š„่Šไธ€่Š says:
    December 20, 2016 at 4:34 pm

    this disease found by Turkish scientist, Dr.behcet. just to inform:))

    Reply
  10. Nobu Nuggets says:
    December 20, 2016 at 5:50 pm

    Can you make a video for Chiari Malformation?

    Reply
  11. Ali Xander says:
    January 11, 2017 at 6:10 pm

    Can you make a video about antibiotics

    Reply
  12. Sefa Kaya says:
    January 26, 2017 at 9:48 pm

    The reading is the illnes is not BIลžET it id BEH ร‡ET

    Reply
  13. Valar Dohearis says:
    January 31, 2017 at 12:55 am

    Behรงet is not autoimmundisease . It is inflammatr disease

    Reply
  14. cassochinadoll says:
    February 1, 2017 at 6:49 pm

    I wish there was a PDF of each disease with the slides presented here all one page for each disease. Would anyone else like this? I'm an osmosis subscriber by the way. Thank you and keep it up!

    Reply
  15. medicine doctor says:
    April 21, 2017 at 1:10 pm

    just proud being turks:)thanks from turkey, alot:)

    Reply
  16. marcela rotre says:
    May 24, 2017 at 4:28 am

    awesome guys! please more autoinmune stuffs

    Reply
  17. manoj kumar says:
    June 15, 2017 at 11:53 am

    best tutorial channel for medicine

    Reply
  18. rushabh raval says:
    June 20, 2017 at 3:51 am

    it's HLA B5 not B51

    Reply
  19. MarcusJay214 says:
    July 9, 2017 at 3:31 am

    thanks for posting this has affected my eyes and this is some awful stuff…..its been a hard journey for me. thanks for sharing. #bechetsawareness

    Reply
  20. rameesnm says:
    July 23, 2017 at 4:17 pm

    pathergy test is done by intra dermal injection of saline

    Reply
  21. kgh3340887 says:
    August 10, 2017 at 6:21 am

    God bless you, from Korean med student

    Reply
  22. Raul Ramirez says:
    August 13, 2017 at 11:29 pm

    How is the diagnosis made and how are the diagnosis diferrentials discarded?

    Reply
  23. Dave C says:
    November 1, 2017 at 3:02 am

    Is there a cure?

    Reply
  24. haitham alashwal says:
    November 27, 2017 at 9:52 am

    G

    Reply
  25. sweetkokii says:
    January 2, 2018 at 5:36 pm

    i just looooooooooove your channel

    Reply
  26. divine says:
    February 7, 2018 at 9:34 pm

    bay – sets

    Reply
  27. The Spiked Giraffe says:
    March 10, 2018 at 8:54 pm

    10 days…that is when I go for a brain biopsy to confirm if I have this. Fingers crossed i don"t…then it's only ADEM to deal with

    Reply
  28. thisnightissparking says:
    March 18, 2018 at 3:26 am

    The quality of illustrations/visuals and depth of information you guys have in each of your videos never ceases to amaze me. Osmosis is an invaluable resource, thank you!!

    Reply
  29. Akira says:
    May 15, 2018 at 11:20 pm

    Behcet syndrome is an autoimmune disorder and if you guys type in Rosie marcel she is a British actor mainly known as jac naylor from Holby city she has it and there is a clip about her explaining it

    Reply
  30. N Zainab says:
    May 20, 2018 at 11:59 am

    Thank you very much

    Reply
  31. Ibtisam Alamin says:
    June 4, 2018 at 1:44 pm

    Thank you๐Ÿ‘Œ๐Ÿ‘

    Reply
  32. de dol says:
    June 6, 2018 at 7:25 am

    Thank you

    Reply
  33. amy hirsch says:
    June 13, 2018 at 5:10 am

    thank you for finally explaining to me my disease. no doctor has been able to tell me exactly what was happening but just told me i had this. thank you so much

    Reply
  34. Amanda Devier says:
    July 25, 2018 at 8:44 pm

    Vaccines cause this ๐Ÿ™„

    Reply
  35. ILIAS AMPELOURGOS says:
    August 5, 2018 at 7:47 pm

    Great channel! Find it very helpful & have used it more than once in my studies as a med student…Only one small correction: it's ''Adamantiades-Behcet'' Disease…

    Reply
  36. yoav cohen says:
    August 15, 2018 at 9:04 am

    I thank you so very much.
    Your easy explanations are amazing.
    For all others if you want current updated info on this terrible illness, search behcet with ncbi.
    That's where the most updated research usually can be found.

    Reply
  37. fahad alrayes says:
    September 7, 2018 at 6:39 pm

    Can any one explaine how this is deferred from systemic lobus?

    Reply
  38. Queen of the Jungle says:
    October 4, 2018 at 5:45 pm

    Thanks for explaining in a more technical way instead of just summing up the common things. I was just diagnosed after years and years of trouble this disease has caused me. Luckily for now- not much changes in eyesight. It was noticed by a doctor finally, when I was recently admitted in hospital for sepsis and I just happened to mention to the dr my ulcers on my privates (which seem to flair when I get sick) after testing negative for every STD they could think of, taking into consideration my long history of GI problems and bleeding, as well as constantly battling different ailments from swollen painful ankles, mouth ulcers, strep like symptoms but never testing positive for strep, tonsillitis, or mono, ect (the long list) we've finally discovered whats been making me suffer for so long. Its hurt relationships, people have accused me of lying, complaining too much, its cost me jobs… just… bleh.

    Reply
  39. kdjdjd mdkdj says:
    October 29, 2018 at 4:38 pm

    ๐Ÿ‡น๐Ÿ‡ท๐Ÿ‡น๐Ÿ‡ท๐Ÿ‡น๐Ÿ‡ท๐Ÿ‡น๐Ÿ‡ท

    Reply
  40. nohashtags says:
    November 4, 2018 at 2:56 pm

    I don't know who you are… I don't know what your name is.. but I'm going to find you.. and going to hug you ! ๐Ÿ˜†

    Reply
  41. Ryan Barrett says:
    November 9, 2018 at 10:50 pm

    Great video! thanks for it

    Reply
  42. Bobbie Cocke says:
    November 12, 2018 at 11:22 pm

    I want to thank you for making this video I have bichette syndrome and it's so hard trying to explain or show somebody how bad the syndrome really is and what it can do to to a person.

    Reply
  43. Ali Blablabla says:
    November 25, 2018 at 5:36 pm

    If I could take back all the money I paid for med school and donated it to you, I would

    Reply
  44. Miranda Harveyy says:
    December 12, 2018 at 11:03 pm

    I have this, im 14 and i was diagnosed when i was 10. Its a living hell… plus i also have scoliosis and kyphosis and disautonomy. I fucking hate this

    Reply
  45. Asu Pelin Akkรถse says:
    February 8, 2019 at 7:09 pm

    Behcet patient here! For treatment medicines that contains colchium is being widely used, as well.

    Reply
  46. Art Lady says:
    June 11, 2019 at 3:49 am

    Fellow sufferer here . May God Bless you if your thinking you may have this . And if not also . Keep fighting . I have it 17 years now . God help the people suffering now who are only learning about this as they arenโ€™t helping with pain meds now . Thank God I had this before or they wouldnโ€™t help me I would be dead from my own hand . Those pain meds keep me alive . I fear for people, who suffer and donโ€™t have cancer . They think only cancer cause s sever pain .

    Reply
  47. Hussien Jabbar says:
    June 12, 2019 at 1:31 pm

    I have bahjet disease ๐Ÿ˜ญ๐Ÿ˜ญ๐Ÿ˜ญ

    Reply
  48. YukinaHikari says:
    June 13, 2019 at 6:48 am

    Thank you for making this video. I have Behcet's, and I am going to share this so my family and friends can understand a little bit more. Again, thank you.

    Reply
  49. Merve Kir says:
    June 24, 2019 at 3:31 pm

    thank you for young the correct term VULVA… usually this should be expected from people who work in the medical field, but most people use the wrong term…

    Reply
  50. Konosa Mero says:
    July 4, 2019 at 8:27 pm

    You are great

    Reply
  51. M D says:
    July 22, 2019 at 4:37 pm

    Behรงet's disease is named after a Turkish scientist, Prof. Dr. Hulusi Behรงet.

    Reply

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recent Posts

  • Greater Vision Showcase Part 4
  • Jim Fortman with Vision Aid Systems, Inc. – Episode 78
  • ๐Ÿ‘๐Ÿ‘LIVER FLUKES IN HUMANS
  • David D. Richardson, MD, Interviews Cataract Surgical Pioneer, Robert M. Sinskey, MD
  • Thyroid Eye Disease
  • Home Remedies for Eye Sty (Stye) – How To Get Rid Of A Eye Stye – Causes, Symptoms & Treatment.
  • Blackheads behind his ear.Thank you for watching.
  • Carl’s Experience in CBT for Chronic Pain
  • ‘Excruciatingly Painful Palm Tattoos’ Flash Challenge Preview | Ink Master: Season 8
  • NEI CFC telethon 2015

Recent Comments

  • Ms Sophia on Blackheads behind his ear.Thank you for watching.
  • lisa phleps on How My Ironman Training Can Help Your Job Search!
  • Doug Blanks on Blackheads behind his ear.Thank you for watching.
  • prometheusfallen on Blackheads behind his ear.Thank you for watching.
  • Matt Holloway on How My Ironman Training Can Help Your Job Search!

Tags

and animation audiology can cure deaf doctor ear education eye eye care eye doctor eyes for funny glaucoma hard-of-hearing health Health (Industry) hearing hearing aid hearing aids Hearing loss home remedies how to like medical medicine News nose ophthalmology pain science surgery symptoms that the this treatment video vision was you your yt:cc=on
©2019 Thrash It Out Online | Built using WordPress and Responsive Blogily theme by Superb